Step-dose IL-7 treatment promotes systemic expansion of T cells and alters immune cell landscape in blood and lymph nodes

Step-dose IL-7 treatment promotes systemic expansion of T cells and alters immune cell landscape in blood and lymph nodes

Summary: We employed a dose-escalation regimen in rhesus macaques to deliver glycosylated IL-7, a cytokine critical for development and maintenance of T lymphocytes. IL-7 increased proliferation and survival of T cells and triggered several chemokines and cytokines. Induction of CXCL13 in lymph node...

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Bibliographic Details
Main Authors: Hrishikesh Pandit, Antonio Valentin, Matthew Angel, Claire Deleage, Cristina Bergamaschi, Jenifer Bear, Raymond Sowder, Barbara K. Felber, George N. Pavlakis
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:iScience
Subjects:
Immune system
Immune response
Components of the immune system
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223000068

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http://www.sciencedirect.com/science/article/pii/S2589004223000068

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