Continuous sensing of nutrients and growth factors by the mTORC1-TFEB axis

Continuous sensing of nutrients and growth factors by the mTORC1-TFEB axis

mTORC1 senses nutrients and growth factors and phosphorylates downstream targets, including the transcription factor TFEB, to coordinate metabolic supply and demand. These functions position mTORC1 as a central controller of cellular homeostasis, but the behavior of this system in individual cells h...

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Bibliographic Details
Main Authors: Breanne Sparta, Nont Kosaisawe, Michael Pargett, Madhura Patankar, Nicholaus DeCuzzi, John G Albeck
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-09-01
Series:eLife
Subjects:
target of rapamycin (mTOR)
cellular metabolism
nutrient sensing
glycogen synthase kinase 3 (GSK3)
AKT
AMP-activated protein kinase (AMPK)
Online Access:https://elifesciences.org/articles/74903

Internet

https://elifesciences.org/articles/74903

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