Evaluation of a connexin-based peptide for the treatment of age-related macular degeneration

Evaluation of a connexin-based peptide for the treatment of age-related macular degeneration

A critical target in age-related macular degeneration (AMD) is the retinal pigment epithelium (RPE), which forms the outer blood-retina barrier (BRB). RPE-barrier dysfunction might result from the disruption of intercellular tight junctions (TJs). A Connexin43 (Cx43)-based peptide, aCT1, has been sh...

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Bibliographic Details
Main Authors: Elisabeth Obert, Christina Grek, Gautam Ghatnekar, Bärbel Rohrer
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Heliyon
Subjects:
Retinal pigment epithelium
Tight junctions
Choroidal neovascularization
Vascular endothelial growth factor
Age-related macular degeneration
aCT1
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844022026470

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http://www.sciencedirect.com/science/article/pii/S2405844022026470

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