Autocrine/Paracrine Loop Between SCF+/c-Kit+ Mast Cells Promotes Cutaneous Melanoma Progression

Autocrine/Paracrine Loop Between SCF+/c-Kit+ Mast Cells Promotes Cutaneous Melanoma Progression

c-Kit, or mast/stem cell growth factor receptor Kit, is a tyrosine kinase receptor structurally analogous to the colony-stimulating factor-1 (CSF-1) and platelet-derived growth factor (PDGF) CSF-1/PDGF receptor Tyr-subfamily. It binds the cytokine KITLG/SCF to regulate cell survival and proliferatio...

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Bibliographic Details
Main Authors: Tiziana Annese, Roberto Tamma, Mariella Bozza, Alfredo Zito, Domenico Ribatti
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
angiogenesis
mast cells
melanoma
tumor progression
tumor microenevironment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.794974/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.794974/full

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