Deleting Mecp2 from the cerebellum rather than its neuronal subtypes causes a delay in motor learning in mice

Deleting Mecp2 from the cerebellum rather than its neuronal subtypes causes a delay in motor learning in mice

Rett syndrome is a devastating childhood neurological disorder caused by mutations in MECP2. Of the many symptoms, motor deterioration is a significant problem for patients. In mice, deleting Mecp2 from the cortex or basal ganglia causes motor dysfunction, hypoactivity, and tremor, which are abnorma...

Full description

Bibliographic Details
Main Authors: Nathan P Achilly, Ling-jie He, Olivia A Kim, Shogo Ohmae, Gregory J Wojaczynski, Tao Lin, Roy V Sillitoe, Javier F Medina, Huda Y Zoghbi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-01-01
Series:eLife
Subjects:
Rett syndrome
cerebellum
motor learning
MeCP2
Online Access:https://elifesciences.org/articles/64833

Internet

https://elifesciences.org/articles/64833

Similar Items