Synthesis and Evaluation of Novel DNA Minor Groove Binders as Antiamoebic Agents

Synthesis and Evaluation of Novel DNA Minor Groove Binders as Antiamoebic Agents

The free-living amoeba <i>Acanthamoeba castellanii</i> is responsible for the central nervous infection granulomatous amoebic encephalitis and sight-threatening infection <i>Acanthamoeba keratitis</i>. Moreover, no effective treatment is currently present, and a combination d...

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Bibliographic Details
Main Authors: Hasan Y. Alniss, Naveed A. Khan, Anania Boghossian, Noor Akbar, Hadeel M. Al-Jubeh, Yousef A. Msallam, Balsam Q. Saeed, Ruqaiyyah Siddiqui
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Antibiotics
Subjects:
<i>Acanthamoeba castellanii</i>
trophozoites
cysts
sight-threatening
DNA minor groove binders
distamycin analogues
Online Access:https://www.mdpi.com/2079-6382/11/7/935

Internet

https://www.mdpi.com/2079-6382/11/7/935

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