Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease
Traditional drug discovery process use differential, Bayesian and other network based approaches. We developed a Boolean approach for building disease maps and prioritizing pre-clinical models to discover a first-in-class therapy to restore and protect the leaky gut barrier in inflammatory bowel dis...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24470-5 |
| _version_ | 1818344108001853440 |
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| author | Debashis Sahoo Lee Swanson Ibrahim M. Sayed Gajanan D. Katkar Stella-Rita Ibeawuchi Yash Mittal Rama F. Pranadinata Courtney Tindle Mackenzie Fuller Dominik L. Stec John T. Chang William J. Sandborn Soumita Das Pradipta Ghosh |
| author_facet | Debashis Sahoo Lee Swanson Ibrahim M. Sayed Gajanan D. Katkar Stella-Rita Ibeawuchi Yash Mittal Rama F. Pranadinata Courtney Tindle Mackenzie Fuller Dominik L. Stec John T. Chang William J. Sandborn Soumita Das Pradipta Ghosh |
| author_sort | Debashis Sahoo |
| collection | DOAJ |
| description | Traditional drug discovery process use differential, Bayesian and other network based approaches. We developed a Boolean approach for building disease maps and prioritizing pre-clinical models to discover a first-in-class therapy to restore and protect the leaky gut barrier in inflammatory bowel disease. |
| first_indexed | 2024-12-13T16:41:14Z |
| format | Article |
| id | doaj.art-d3b3157a040445e7931fa319037c2287 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:41:14Z |
| publishDate | 2021-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d3b3157a040445e7931fa319037c22872022-12-21T23:38:16ZengNature PortfolioNature Communications2041-17232021-07-0112111410.1038/s41467-021-24470-5Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel diseaseDebashis Sahoo0Lee Swanson1Ibrahim M. Sayed2Gajanan D. Katkar3Stella-Rita Ibeawuchi4Yash Mittal5Rama F. Pranadinata6Courtney Tindle7Mackenzie Fuller8Dominik L. Stec9John T. Chang10William J. Sandborn11Soumita Das12Pradipta Ghosh13Department of Pediatrics, University of California San DiegoDepartment of Cellular and Molecular Medicine, University of California San DiegoDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Assiut UniversityDepartment of Cellular and Molecular Medicine, University of California San DiegoDepartment of Pathology, University of California San DiegoDepartment of Medicine, University of California San DiegoDepartment of Cellular and Molecular Medicine, University of California San DiegoDepartment of Cellular and Molecular Medicine, University of California San DiegoDepartment of Cellular and Molecular Medicine, University of California San DiegoDepartment of Cellular and Molecular Medicine, University of California San DiegoDepartment of Medicine, University of California San DiegoDepartment of Medicine, University of California San DiegoDepartment of Pathology, University of California San DiegoRebecca and John Moore Comprehensive Cancer Center, University of California San DiegoTraditional drug discovery process use differential, Bayesian and other network based approaches. We developed a Boolean approach for building disease maps and prioritizing pre-clinical models to discover a first-in-class therapy to restore and protect the leaky gut barrier in inflammatory bowel disease.https://doi.org/10.1038/s41467-021-24470-5 |
| spellingShingle | Debashis Sahoo Lee Swanson Ibrahim M. Sayed Gajanan D. Katkar Stella-Rita Ibeawuchi Yash Mittal Rama F. Pranadinata Courtney Tindle Mackenzie Fuller Dominik L. Stec John T. Chang William J. Sandborn Soumita Das Pradipta Ghosh Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease Nature Communications |
| title | Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease |
| title_full | Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease |
| title_fullStr | Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease |
| title_full_unstemmed | Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease |
| title_short | Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease |
| title_sort | artificial intelligence guided discovery of a barrier protective therapy in inflammatory bowel disease |
| url | https://doi.org/10.1038/s41467-021-24470-5 |
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