Encapsulation of MERS antigen into α-GalCer-bearing-liposomes elicits stronger effector and memory immune responses in immunocompetent and leukopenic mice

Encapsulation of MERS antigen into α-GalCer-bearing-liposomes elicits stronger effector and memory immune responses in immunocompetent and leukopenic mice

Objectives: Here, we prepared a liposome-based vaccine formulation containing Middle East Respiratory Syndrome Coronavirus papain-like protease (MERS-CoV-PLpro). Methods: A persistent leukopenic condition was induced in mice by injecting cyclophosphamide (CYP) three days before each dose of immuniza...

Full description

Bibliographic Details
Main Authors: Masood Alam Khan, Arif Khan, Mohammad A. Alzohairy, Abdulmohsen M. Alruwetei, Mohammed A. Alsahli, Khaled S. Allemailem, Faris Alrumaihi, Ahmad Almatroudi, Bader Y. Alhatlani, Osamah Al Rugaie, Ajamaluddin Malik
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Journal of King Saud University: Science
Subjects:
Immunization
Liposome
MERS-CoV
NKT cell
Online Access:http://www.sciencedirect.com/science/article/pii/S1018364722003056

Internet

http://www.sciencedirect.com/science/article/pii/S1018364722003056

Similar Items