Anti-Alzheimer Activity of Combinations of Cocoa with Vinpocetine or Other Nutraceuticals in Rat Model: Modulation of Wnt3/β-Catenin/GSK-3β/Nrf2/HO-1 and PERK/CHOP/Bcl-2 Pathways

Anti-Alzheimer Activity of Combinations of Cocoa with Vinpocetine or Other Nutraceuticals in Rat Model: Modulation of Wnt3/β-Catenin/GSK-3β/Nrf2/HO-1 and PERK/CHOP/Bcl-2 Pathways

Alzheimer’s disease (AD) is a devastating illness with limited therapeutic interventions. The aim of this study is to investigate the pathophysiological mechanisms underlying AD and explore the potential neuroprotective effects of cocoa, either alone or in combination with other nutraceuticals, in a...

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Main Authors: Karema Abu-Elfotuh, Amina M. A. Tolba, Furqan H. Hussein, Ahmed M. E. Hamdan, Mohamed A. Rabeh, Saad A. Alshahri, Azza A. Ali, Sarah M. Mosaad, Nihal A. Mahmoud, Magdy Y. Elsaeed, Ranya M. Abdelglil, Rehab R. El-Awady, Eman Reda M. Galal, Mona M. Kamal, Ahmed M. M. Elsisi, Alshaymaa Darwish, Ayah M. H. Gowifel, Yasmen F. Mahran
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Pharmaceutics
Subjects:
Alzheimer’s disease
GSK-3β-Wnt/β-catenin
PERK/CHOP/Bcl-2
oxidative stress
cocoa
vinpocetine
Online Access:https://www.mdpi.com/1999-4923/15/8/2063

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https://www.mdpi.com/1999-4923/15/8/2063

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