A carrier-free supramolecular nano-twin-drug for overcoming irinotecan-resistance and enhancing efficacy against colorectal cancer

A carrier-free supramolecular nano-twin-drug for overcoming irinotecan-resistance and enhancing efficacy against colorectal cancer

Abstract Irinotecan (Ir) is commonly employed as a first-line chemotherapeutic treatment for colorectal cancer (CRC). However, tremendous impediments remain to be addressed to surmount drug resistance and ameliorate adverse events. Poly-ADP-Ribose Polymerase (PARP) participates in the maintenance of...

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Bibliographic Details
Main Authors: Miaomiao Yuan, Tong Chen, Lu Jin, Peng Zhang, Luoyijun Xie, Shuyi Zhou, Lianfeng Fan, Li Wang, Cai Zhang, Ning Tang, LiHao Guo, Chengmei Xie, Yanhong Duo, Ling Li, Leilei Shi
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Nanobiotechnology
Subjects:
Carrier-free
Supramolecular self-assembly
Nano-twin-drug
Irinotecan-resistance
Colorectal cancer
Online Access:https://doi.org/10.1186/s12951-023-02157-x

Internet

https://doi.org/10.1186/s12951-023-02157-x

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