A Marine Analgesic Peptide, Contulakin-G, and Neurotensin are Distinct Agonists for Neurotensin Receptors: Uncovering Structural Determinants of Desensitization Properties

A Marine Analgesic Peptide, Contulakin-G, and Neurotensin are Distinct Agonists for Neurotensin Receptors: Uncovering Structural Determinants of Desensitization Properties

Neurotensin receptors have been studied as molecular targets for the treatment of pain, schizophrenia, addiction, or cancer. Neurotensin (NT) and Contulakin-G, a glycopeptide isolated from a predatory cone snail Conus geographus, share a sequence similarity at the C-terminus, which is critical for a...

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Bibliographic Details
Main Authors: Hee-Kyoung eLee, Liuyin eZhang, Misty D Smith, Aleksandra eWalewska, Nadeem eVellore, Riccardo eBaron, J Michael eMcIntosh, H Steve eWhite, Baldomero M Olivera, Grzegorz eBulaj
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Pharmacology
Subjects:
Analgesics
Conotoxins
Desensitization, Immunologic
Neuropeptides
Neurotensin
Pain
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00011/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00011/full

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