Generation of two homozygous SHOX2 knock-out human induced pluripotent stem cell lines using CRISPR/Cas9

Generation of two homozygous SHOX2 knock-out human induced pluripotent stem cell lines using CRISPR/Cas9

SHOX2 is a homeobox transcription factor associated with atrial fibrillation (AF) and sinus node dysfunction. Here, we generated two homozygous SHOX2 knock-out hiPSC lines from a healthy control line and a corrected AF patient line (disease-specific SHOX2 mutation corrected to WT) using CRISPR/Cas9....

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Bibliographic Details
Main Authors: Kristin Rädecke, Ambuj Gore, Karin Burau, Magdalena Laugsch, Katrin Köhler, Gudrun A Rappold, Sandra Hoffmann
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506123000752

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http://www.sciencedirect.com/science/article/pii/S1873506123000752

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