REV-ERBα regulates age-related and oxidative stress-induced degeneration in retinal pigment epithelium via NRF2

REV-ERBα regulates age-related and oxidative stress-induced degeneration in retinal pigment epithelium via NRF2

Retinal pigment epithelium (RPE) dysfunction and atrophy occur in dry age-related macular degeneration (AMD), often leading to photoreceptor degeneration and vision loss. Accumulated oxidative stress during aging contributes to RPE dysfunction and degeneration. Here we show that the nuclear receptor...

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Bibliographic Details
Main Authors: Shuo Huang, Chi-Hsiu Liu, Zhongxiao Wang, Zhongjie Fu, William R. Britton, Alexandra K. Blomfield, Theodore M. Kamenecka, Joshua L. Dunaief, Laura A. Solt, Jing Chen
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Redox Biology
Subjects:
Retinal pigment epithelium
Aging
Age-related macular degeneration
REV-ERBα
Oxidative damage
NRF2
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722000337

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http://www.sciencedirect.com/science/article/pii/S2213231722000337

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