REV-ERBα regulates age-related and oxidative stress-induced degeneration in retinal pigment epithelium via NRF2
Retinal pigment epithelium (RPE) dysfunction and atrophy occur in dry age-related macular degeneration (AMD), often leading to photoreceptor degeneration and vision loss. Accumulated oxidative stress during aging contributes to RPE dysfunction and degeneration. Here we show that the nuclear receptor...
Main Authors: | Shuo Huang, Chi-Hsiu Liu, Zhongxiao Wang, Zhongjie Fu, William R. Britton, Alexandra K. Blomfield, Theodore M. Kamenecka, Joshua L. Dunaief, Laura A. Solt, Jing Chen |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2022-05-01
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Series: | Redox Biology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231722000337 |
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