Exendin-4 Preserves Blood-Brain Barrier Integrity via Glucagon-Like Peptide 1 Receptor/Activated Protein Kinase-Dependent Nuclear Factor-Kappa B/Matrix Metalloproteinase-9 Inhibition After Subarachnoid Hemorrhage in Rat

Exendin-4 Preserves Blood-Brain Barrier Integrity via Glucagon-Like Peptide 1 Receptor/Activated Protein Kinase-Dependent Nuclear Factor-Kappa B/Matrix Metalloproteinase-9 Inhibition After Subarachnoid Hemorrhage in Rat

In this study, we investigated the role of Exendin-4 (Ex-4), a glucagon-like peptide 1 receptor (GLP-1R) agonist, in blood-brain barrier (BBB) disruption after subarachnoid hemorrhage (SAH) in rats. The endovascular perforation model of SAH was performed in Sprague-Dawley rats. Ex-4 was intraperiton...

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Bibliographic Details
Main Authors: Zhiyi Xie, Budbazar Enkhjargal, Matei Nathanael, Lingyun Wu, Qiquan Zhu, Tongyu Zhang, Jiping Tang, John H. Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
AMPK
blood-brain barrier
Exendin-4
GLP-1r
subarachnoid hemorrhage
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.750726/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2021.750726/full

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