Regulation of PD-L1: Emerging Routes for Targeting Tumor Immune Evasion

Regulation of PD-L1: Emerging Routes for Targeting Tumor Immune Evasion

Immune checkpoint blockade therapies (ICBTs) targeting programmed cell death 1 (PD-1) and its ligand programmed death ligand-1 (PD-L1/B7-H1/CD274) have exhibited momentous clinical benefits and durable responses in multiple tumor types. However, primary resistance is found in considerable number of...

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Bibliographic Details
Main Authors: Yiting Wang, Huanbin Wang, Han Yao, Chushu Li, Jing-Yuan Fang, Jie Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Pharmacology
Subjects:
PD-L1
immunotherapy
gene expression
post-translational modification
small molecular inhibitors
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00536/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00536/full

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