Construction of a Stable and Temperature-Responsive Yeast Cell Factory for Crocetin Biosynthesis Using CRISPR-Cas9

Construction of a Stable and Temperature-Responsive Yeast Cell Factory for Crocetin Biosynthesis Using CRISPR-Cas9

Crocetin is a plant natural product with broad medicinal applications, such as improvement of sleep quality and attenuation of physical fatigue. However, crocetin production using microbial cell factories is still far from satisfaction, probably due to the conflict between cell growth and product ac...

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Bibliographic Details
Main Authors: Tengfei Liu, Chang Dong, Mingming Qi, Bei Zhang, Lei Huang, Zhinan Xu, Jiazhang Lian
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
crocetin
temperature switch
copy number
genome integration
CRISPR-Cas9
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00653/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.00653/full

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