Striatal astrocytes act as a reservoir for L-DOPA.

Striatal astrocytes act as a reservoir for L-DOPA.

L-DOPA is therapeutically efficacious in patients with Parkinson's disease (PD), although dopamine (DA) neurons are severely degenerated. Since cortical astrocytes express neutral amino acid transporter (LAT) and DA transporter (DAT), the uptake and metabolism of L-DOPA and DA in striatal astro...

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Bibliographic Details
Main Authors: Masato Asanuma, Ikuko Miyazaki, Shinki Murakami, Francisco J Diaz-Corrales, Norio Ogawa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25188235/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25188235/?tool=EBI

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