Disturbed sleep is associated with reduced verbal episodic memory and entorhinal cortex volume in younger middle-aged women with risk-reducing early ovarian removal

Disturbed sleep is associated with reduced verbal episodic memory and entorhinal cortex volume in younger middle-aged women with risk-reducing early ovarian removal

IntroductionWomen with early ovarian removal (<48 years) have an elevated risk for both late-life Alzheimer’s disease (AD) and insomnia, a modifiable risk factor. In early midlife, they also show reduced verbal episodic memory and hippocampal volume. Whether these reductions correlate with a...

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Bibliographic Details
Main Authors: Nicole J. Gervais, Laura Gravelsins, Alana Brown, Rebekah Reuben, Mateja Perovic, Laurice Karkaby, Gina Nicoll, Kazakao Laird, Shreeyaa Ramana, Marcus Q. Bernardini, Michelle Jacobson, Lea Velsher, William Foulkes, M. Natasha Rajah, Rosanna K. Olsen, Cheryl Grady, Gillian Einstein
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Endocrinology
Subjects:
bilateral salpingo-oophorectomy
BRCA1/2
estradiol
sleep phenotype
verbal episodic memory
structural neuroimaging
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1265470/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1265470/full

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