Skeletal myotubes expressing ALS mutant SOD1 induce pathogenic changes, impair mitochondrial axonal transport, and trigger motoneuron death

Skeletal myotubes expressing ALS mutant SOD1 induce pathogenic changes, impair mitochondrial axonal transport, and trigger motoneuron death

Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the loss of motoneurons (MNs), and despite progress, there is no effective treatment. A large body of evidence shows that astrocytes expressing ALS-linked mutant proteins cause non-cell autonomous toxi...

詳細記述

書誌詳細
主要な著者: Pablo Martínez, Mónica Silva, Sebastián Abarzúa, María Florencia Tevy, Enrique Jaimovich, Martha Constantine-Paton, Fernando J. Bustos, Brigitte van Zundert
フォーマット: 論文
言語:English
出版事項: BMC 2024-10-01
シリーズ:Molecular Medicine
主題:
ALS
Myotubes
Muscle
Motoneuron
Axonopathy
Mitochondria
オンライン･アクセス:https://doi.org/10.1186/s10020-024-00942-4

インターネット

https://doi.org/10.1186/s10020-024-00942-4

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