T Regulatory Cell-Associated Tolerance Induction by High-Dose Immunoglobulins in an HLA-Transgenic Mouse Model of Pemphigus

T Regulatory Cell-Associated Tolerance Induction by High-Dose Immunoglobulins in an HLA-Transgenic Mouse Model of Pemphigus

Pemphigus vulgaris (PV) is a potentially lethal autoimmune bullous skin disorder caused by IgG autoantibodies against desmoglein 3 (Dsg3) and Dsg1. During the last three decades, high-dose intravenous immunoglobulins (IVIgs) have been applied as an effective and relatively safe treatment regime in s...

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Bibliographic Details
Main Authors: Christoph Hudemann, Jochen Hoffmann, Enno Schmidt, Michael Hertl, Rüdiger Eming
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cells
Subjects:
pemphigus vulgaris
desmoglein
IVIg
antibodies
autoimmunity
Online Access:https://www.mdpi.com/2073-4409/12/9/1340

Internet

https://www.mdpi.com/2073-4409/12/9/1340

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