Rimonabant Kills Colon Cancer Stem Cells without Inducing Toxicity in Normal Colon Organoids

Colorectal cancer (CRC), like other tumor types, is a highly heterogeneous disease. Within the tumor bulk, intra-tumoral heterogeneity is also ascribable to Cancer Stem Cells (CSCs) subpopulation, characterized by high chemoresistance and the unique ability to retain tumorigenic potential, thus asso...

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Bibliographic Details
Main Authors: Donatella Fiore, Prashanthi Ramesh, Maria C. Proto, Chiara Piscopo, Silvia Franceschelli, Serena Anzelmo, Jan P. Medema, Maurizio Bifulco, Patrizia Gazzerro
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00949/full