Rimonabant Kills Colon Cancer Stem Cells without Inducing Toxicity in Normal Colon Organoids
Colorectal cancer (CRC), like other tumor types, is a highly heterogeneous disease. Within the tumor bulk, intra-tumoral heterogeneity is also ascribable to Cancer Stem Cells (CSCs) subpopulation, characterized by high chemoresistance and the unique ability to retain tumorigenic potential, thus asso...
Main Authors: | Donatella Fiore, Prashanthi Ramesh, Maria C. Proto, Chiara Piscopo, Silvia Franceschelli, Serena Anzelmo, Jan P. Medema, Maurizio Bifulco, Patrizia Gazzerro |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2018-01-01
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Series: | Frontiers in Pharmacology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/article/10.3389/fphar.2017.00949/full |
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