Computer Modeling of Clonal Dominance: Memory-Anti-Naïve and Its Curbing by Attrition

Experimental and computational studies have revealed that T-cell cross-reactivity is a widespread phenomenon that can either be advantageous or detrimental to the host. In particular, detrimental effects can occur whenever the clonal dominance of memory cells is not justified by their infection-clea...

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Bibliographic Details
Main Authors: Filippo Castiglione, Dario Ghersi, Franco Celada
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01513/full