Does random treatment assignment cause harm to research participants?

Some argue that by precluding individualized treatment, randomized clinical trials (RCTs) provide substandard medical care, while others claim that participation in clinical research is associated with improved patient outcomes. However, there are few data to assess the impact of random treatment as...

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Bibliographic Details
Main Authors: Cary P Gross, Harlan M Krumholz, Gretchen Van Wye, Ezekiel J Emanuel, David Wendler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-06-01
Series:PLoS Medicine
Online Access:http://europepmc.org/articles/PMC1470665?pdf=render