The inactivation of tolC sensitizes Escherichia coli to perturbations in lipopolysaccharide transport

Summary: The Escherichia coli outer membrane channel TolC complexes with several inner membrane efflux pumps to export compounds across the cell envelope. All components of these complexes are essential for robust efflux activity, yet E. coli is more sensitive to antimicrobial compounds when tolC is...

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Bibliographic Details
Main Authors: Shawna Zhu, Mary Kate Alexander, Telmo O. Paiva, Kenneth Rachwalski, Anh Miu, Yiming Xu, Vishal Verma, Mike Reichelt, Yves F. Dufrêne, Eric D. Brown, Georgina Cox
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224008149