Neuronal-specific TNFAIP1 ablation attenuates postoperative cognitive dysfunction via targeting SNAP25 for K48-linked ubiquitination

Neuronal-specific TNFAIP1 ablation attenuates postoperative cognitive dysfunction via targeting SNAP25 for K48-linked ubiquitination

Abstract Background Synaptosomal-associated protein 25 (SNAP25) exerts protective effects against postoperative cognitive dysfunction (POCD) by promoting PTEN-induced kinase 1 (PINK1)/Parkin-mediated mitophagy and repressing caspase-3/gasdermin E (GSDME)-mediated pyroptosis. However, the regulatory...

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Bibliographic Details
Main Authors: Wei Wang, Wenwei Gao, Ping Gong, Wenqin Song, Xueshan Bu, Jiabao Hou, Lei Zhang, Bo Zhao
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Cell Communication and Signaling
Subjects:
TNFAIP1
SNAP25
Ubiquitination
Postoperative cognitive dysfunction
Mitophagy
Pyroptosis
Online Access:https://doi.org/10.1186/s12964-023-01390-z

Internet

https://doi.org/10.1186/s12964-023-01390-z

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