Neuronal-specific TNFAIP1 ablation attenuates postoperative cognitive dysfunction via targeting SNAP25 for K48-linked ubiquitination
Abstract Background Synaptosomal-associated protein 25 (SNAP25) exerts protective effects against postoperative cognitive dysfunction (POCD) by promoting PTEN-induced kinase 1 (PINK1)/Parkin-mediated mitophagy and repressing caspase-3/gasdermin E (GSDME)-mediated pyroptosis. However, the regulatory...
Main Authors: | Wei Wang, Wenwei Gao, Ping Gong, Wenqin Song, Xueshan Bu, Jiabao Hou, Lei Zhang, Bo Zhao |
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Format: | Article |
Language: | English |
Published: |
BMC
2023-12-01
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Series: | Cell Communication and Signaling |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12964-023-01390-z |
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