Protective Effects of Smilax glabra Roxb. Against Lead-Induced Renal Oxidative Stress, Inflammation and Apoptosis in Weaning Rats and HEK-293 Cells

Protective Effects of Smilax glabra Roxb. Against Lead-Induced Renal Oxidative Stress, Inflammation and Apoptosis in Weaning Rats and HEK-293 Cells

Lead (Pb) is an important environmental pollutant. Oxidative stress and the inflammatory response have been postulated as mechanisms involved in lead-induced renal damage. Smilax glabra Roxb. has been used for treatment of heavy-metal poisoning in China for 500 years. We investigated S. glabra flavo...

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Bibliographic Details
Main Authors: Yueyue Shi, Chongmei Tian, Xinfen Yu, Yuejuan Fang, Xinyu Zhao, Xiaoxi Zhang, Daozong Xia
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
Smilax glabra Roxb.
lead-induced nephrotoxicity
apoptosis
oxidative stress
inflammatory pathway
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.556248/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.556248/full

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