Influence of histone deacetylase inhibitors and DNA-methyltransferase inhibitors on the NK cell-mediated lysis of pediatric B-lineage leukemia.

Influence of histone deacetylase inhibitors and DNA-methyltransferase inhibitors on the NK cell-mediated lysis of pediatric B-lineage leukemia.

Epigenetic drugs like histone deacetylase inhibitors and DNA methyltransferase inhibitors have been shown to be effective against a variety of tumor entities. Among different molecular anticancer activities of epigenetic active substances, up-regulation of NK cell ligands was described to contribute...

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Bibliographic Details
Main Authors: Matthias Manuel Pfeiffer, Helen eBurrow, Sabine eSchleicher, Rupert eHandgretinger, Peter eLang
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-04-01
Series:Frontiers in Oncology
Subjects:
Immunotherapy
NK cells
HDACi
DNMTi
pediatric lymphoblastic leukemia
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00099/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00099/full

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