Network pharmacology combined with Mendelian randomization analysis to identify the key targets of renin-angiotensin-aldosterone system inhibitors in the treatment of diabetic nephropathy

Network pharmacology combined with Mendelian randomization analysis to identify the key targets of renin-angiotensin-aldosterone system inhibitors in the treatment of diabetic nephropathy

BackgroundDiabetic Nephropathy (DN) is one of the microvascular complications of diabetes. The potential targets of renin-angiotensin-aldosterone system (RAAS) inhibitors for the treatment of DN need to be explored.MethodsThe GSE96804 and GSE1009 datasets, 729 RAAS inhibitors-related targets and 6,0...

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Bibliografske podrobnosti
Main Authors: Dongqi Zhou, Ting Zhou, Shiyun Tang, Qing Li, Wen Li, Gaofeng Gan, Mingqiao Li, Qiu Chen
Format: Article
Jezik:English
Izdano: Frontiers Media S.A. 2024-01-01
Serija:Frontiers in Endocrinology
Teme:
diabetic nephropathy
GEO
network pharmacology
mendelian randomization
acute kidney injury
Online dostop:https://www.frontiersin.org/articles/10.3389/fendo.2024.1354950/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2024.1354950/full

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