The p38/MK2 Pathway Functions as Chk1-Backup Downstream of ATM/ATR in G<sub>2</sub>-Checkpoint Activation in Cells Exposed to Ionizing Radiation
We have recently reported that in G<sub>2</sub>-phase cells (but not S-phase cells) sustaining low loads of DNA double-strand break (DSBs), ATM and ATR regulate the G<sub>2</sub>-checkpoint epistatically, with ATR at the output-node, interfacing with the cell cycle through Ch...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/12/10/1387 |