The p38/MK2 Pathway Functions as Chk1-Backup Downstream of ATM/ATR in G<sub>2</sub>-Checkpoint Activation in Cells Exposed to Ionizing Radiation

The p38/MK2 Pathway Functions as Chk1-Backup Downstream of ATM/ATR in G<sub>2</sub>-Checkpoint Activation in Cells Exposed to Ionizing Radiation

We have recently reported that in G<sub>2</sub>-phase cells (but not S-phase cells) sustaining low loads of DNA double-strand break (DSBs), ATM and ATR regulate the G<sub>2</sub>-checkpoint epistatically, with ATR at the output-node, interfacing with the cell cycle through Ch...

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Bibliographic Details
Main Authors: Daxian Luo, Emil Mladenov, Aashish Soni, Martin Stuschke, George Iliakis
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cells
Subjects:
checkpoints
G<sub>2</sub>-checkpoint
MK2
p38
Chk1
MAP-kinases
Online Access:https://www.mdpi.com/2073-4409/12/10/1387

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