Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease

Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease

β-Amyloid (Aβ) plaques in Alzheimer (AD) brains are surrounded by severe dendritic and axonal changes, including local spine loss, axonal swellings and distorted neurite trajectories. Whether and how plaques induce these neuropil abnormalities remains unknown. We tested the hypothesis that oligomeri...

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Bibliographic Details
Main Authors: B. DaRocha-Souto, M. Coma, B.G. Pérez-Nievas, T.C. Scotton, M. Siao, P. Sánchez-Ferrer, T. Hashimoto, Z. Fan, E. Hudry, I. Barroeta, L. Serenó, M. Rodríguez, M.B. Sánchez, B.T. Hyman, T. Gómez-Isla
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111002993

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http://www.sciencedirect.com/science/article/pii/S0969996111002993

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