Bone Marrow-Derived Stem Cell Factor Regulates Prostate Cancer-Induced Shifts in Pre-Metastatic Niche Composition

Bone Marrow-Derived Stem Cell Factor Regulates Prostate Cancer-Induced Shifts in Pre-Metastatic Niche Composition

Skeletal metastasis is the leading cause of morbidity and mortality in prostate cancer, with 80% of advanced prostate cancer patients developing bone metastases. Before metastasis, bone remodeling occurs, stimulating pre-metastatic niche formation and bone turnover, and platelets govern this process...

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Bibliographic Details
Main Authors: Brittni M. Foster, Lihong Shi, Koran S. Harris, Chirayu Patel, Victoria E. Surratt, Kendall L. Langsten, Bethany A. Kerr
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Oncology
Subjects:
stem cell factor
CD117/c-kit
prostate cancer
bone microenvironment
platelet
osteoblast
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.855188/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.855188/full

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