Securin overexpression correlates with the activated Rb/E2F1 pathway and histone H3 epigenetic modifications in raw areca nut-induced carcinogenesis in mice

Securin overexpression correlates with the activated Rb/E2F1 pathway and histone H3 epigenetic modifications in raw areca nut-induced carcinogenesis in mice

Abstract Background Raw areca nut (RAN) consumption induces oral, esophageal and gastric cancers, which are significantly associated with the overexpression of pituitary tumor transforming gene 1/securin and chromosomal instability (CIN). An association of Securin/PTTG1 upregulation and gastric canc...

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Bibliographic Details
Main Authors: Nabamita Boruah, Chongtham Sovachandra Singh, Pooja Swargiary, Hughbert Dkhar, Anupam Chatterjee
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Cancer Cell International
Subjects:
PTTG1/Securin gene
Histone methylation
Histone acetylation
Rb phosphorylation
Online Access:https://doi.org/10.1186/s12935-022-02442-z

Internet

https://doi.org/10.1186/s12935-022-02442-z

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