Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish

Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish

The pancreatic islet, a cellular community harboring the insulin-producing beta-cells, is known to undergo age-related alterations. However, only a handful of signals associated with aging have been identified. By comparing beta-cells from younger and older zebrafish, here we show that the aging isl...

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Bibliographic Details
Main Authors: Sharan Janjuha, Sumeet Pal Singh, Anastasia Tsakmaki, S Neda Mousavy Gharavy, Priyanka Murawala, Judith Konantz, Sarah Birke, David J Hodson, Guy A Rutter, Gavin A Bewick, Nikolay Ninov
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-04-01
Series:eLife
Subjects:
Diabetes
Inflammation
beta-cells
zebrafish
NF-kB
pancreas
Online Access:https://elifesciences.org/articles/32965

Internet

https://elifesciences.org/articles/32965

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