Crucial Roles of 5-HT and 5-HT2 Receptor in Diabetes-Related Lipid Accumulation and Pro-Inflammatory Cytokine Generation in Hepatocytes

Crucial Roles of 5-HT and 5-HT2 Receptor in Diabetes-Related Lipid Accumulation and Pro-Inflammatory Cytokine Generation in Hepatocytes

Background/Aims: Previously, we confirmed that liver-synthesized 5-HT rather than non-liver 5-HT, acting on the 5-HT2 receptor (5-HT2R), modulates lipid-induced excessive lipid synthesis (ELS). Here, we further revealed the effects of the hepatocellular 5-HT system in diabetes-related disorders. Met...

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Bibliographic Details
Main Authors: Jihua Fu, Chen Li, Guangli Zhang, Xin Tong, Haiwei Zhang, Jie Ding, Yingying Ma, Ru Cheng, Shanshan Hou, Shanshan An, Xin Li, Shaoxin Ma
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
Monoamine oxidase A
Diabetic hepatic disease
5-HT synthesis
5-HT2 receptor
Protein kinase C epsilon
5-HT degradation
Online Access:https://www.karger.com/Article/FullText/492656

Internet

https://www.karger.com/Article/FullText/492656

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