Crucial Roles of 5-HT and 5-HT2 Receptor in Diabetes-Related Lipid Accumulation and Pro-Inflammatory Cytokine Generation in Hepatocytes

Crucial Roles of 5-HT and 5-HT2 Receptor in Diabetes-Related Lipid Accumulation and Pro-Inflammatory Cytokine Generation in Hepatocytes

Background/Aims: Previously, we confirmed that liver-synthesized 5-HT rather than non-liver 5-HT, acting on the 5-HT2 receptor (5-HT2R), modulates lipid-induced excessive lipid synthesis (ELS). Here, we further revealed the effects of the hepatocellular 5-HT system in diabetes-related disorders. Met...

Full description

Bibliographic Details
Main Authors:	Jihua Fu, Chen Li, Guangli Zhang, Xin Tong, Haiwei Zhang, Jie Ding, Yingying Ma, Ru Cheng, Shanshan Hou, Shanshan An, Xin Li, Shaoxin Ma
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2018-08-01
Series:	Cellular Physiology and Biochemistry
Subjects:	Monoamine oxidase A Diabetic hepatic disease 5-HT synthesis 5-HT2 receptor Protein kinase C epsilon 5-HT degradation
Online Access:	https://www.karger.com/Article/FullText/492656

Similar Items

5-HT Receptors and Temperature Homeostasis
by: Irina P. Voronova
Published: (2021-12-01)

Changes of Serotonin (5-HT), 5-HT2A Receptor, and 5-HT Transporter in the Sprague-Dawley Rats of Depression, Myocardial Infarction and Myocardial Infarction Co-exist with Depression
by: Mei-Yan Liu, et al.
Published: (2015-01-01)

Disturbed relationship between glucocorticoid receptor and 5-HT1AR/5-HT2AR in ADHD rats: A correlation study
by: Xiaoxia Lin, et al.
Published: (2023-01-01)

Role of 5-HT7 receptors in the immune system in health and disease
by: Alejandro Quintero-Villegas, et al.
Published: (2019-12-01)

Editorial: 5-HT2A/2B/2C receptors, memory and neuropsychiatric disorders
by: Alfredo eMeneses, et al.
Published: (2016-02-01)

Serotonin 5-HT2A, 5-HT2c and 5-HT1A receptor involvement in the acute effects of psilocybin in mice. In vitro pharmacological profile and modulation of thermoregulation and head-twich response
by: I. Erkizia-Santamaría, et al.
Published: (2022-10-01)

Effect of sarpogrelate treatment on 5-HT modulation of vascular sympathetic innervation and platelet activity in diabetic rats
by: Juan Francisco Fernández-González, et al.
Published: (2022-09-01)

5-HT3 receptor antagonists protect against pressure overload-induced cardiac hypertrophy in murine
by: Rong Huo, et al.
Published: (2012-02-01)

Polymorphism of the serotonin 5HT1A receptor genes 5HT2A and in the diagnosis of overactive bladder in women (study results)
by: F N Makhmejanova, et al.
Published: (2014-02-01)

β-arrestin biased signaling is not involved in the hypotensive actions of 5-HT7 receptor stimulation: use of Serodolin
by: Stephanie W. Watts, et al.
Published: (2024-01-01)

Holographic Quantitative Structure-Activity Relationships of Tryptamine Derivatives at NMDA, 5HT1A and 5HT2A Receptors
by: Peter Wolschann, et al.
Published: (2013-07-01)

Both exogenous 5-HT and endogenous 5-HT, released by fluoxetine, enhance distension evoked propulsion in guinea-pig ileum in vitro
by: Rachel M Gwynne, et al.
Published: (2014-09-01)

Skin Vascular Resistance Decreases during 5-HT-Induced Hypotension in the Rat
by: Benjamin Butler, et al.
Published: (2023-02-01)

Genome-Wide Identification of 5-HT Receptor Gene Family in Razor Clam <i>Sinonovacula constricta</i> and Their Circadian Rhythm Expression Analysis
by: Qiyi You, et al.
Published: (2023-10-01)

Binding and functional structure-activity similarities of 4-substituted 2,5-dimethoxyphenyl isopropylamine analogues at 5-HT2A and 5-HT2B serotonin receptors
by: Prithvi Hemanth, et al.
Published: (2023-01-01)

Pathological Insight into 5-HT<sub>2B</sub> Receptor Activation in Fibrosing Interstitial Lung Diseases
by: Anna Löfdahl, et al.
Published: (2020-12-01)

Combined Antagonism of 5-HT<sub>2</sub> and NMDA Receptors Reduces the Aggression of Monoamine Oxidase a Knockout Mice
by: Roberto Frau, et al.
Published: (2022-02-01)

MAOB rs3027452 Modifies Mood Improvement After Tryptophan Supplementation
by: Gonzalez I, et al.
Published: (2021-05-01)

Role of 5-HT3 Receptors in the Antidepressant Response
by: Connie Sanchez, et al.
Published: (2011-04-01)

Chronic Fluoxetine Impairs the Effects of 5-HT1A and 5-HT2C Receptors Activation in the PAG and Amygdala on Antinociception Induced by Aversive Situation in Mice
by: Daniela Baptista-de-Souza, et al.
Published: (2020-03-01)

A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer’s Disease
by: Bérénice Hatat, et al.
Published: (2019-06-01)

Synergistic Interaction of 5-HT<sub>1B</sub> and 5-HT<sub>2B</sub> Receptors in Cytoplasmic Ca<sup>2+</sup> Regulation in Human Umbilical Vein Endothelial Cells: Possible Involvement in Pathologies
by: Elena Yu. Rybakova, et al.
Published: (2023-09-01)

5-HT3 antagonist for cognition improvement in schizophrenia: a double blind, placebo-controlled trial
by: Neyousha Mohammadi, et al.
Published: (2010-01-01)

5-HT3 antagonist for cognition improvement in schizophrenia: a double blind, placebo-controlled trial
by: Neyousha Mohammadi, et al.
Published: (2010-01-01)

Role of central vagal 5-HT3 receptors in gastrointestinal physiology and pathophysiology
by: Kirsteen eBrowning
Published: (2015-10-01)

Neuronal localization of the 5-HT2 receptor family in the amygdaloid complex
by: Cristiano eBombardi
Published: (2014-04-01)

The Relationship between Overweight/Obesity and Executive Control in College Students: The Mediating Effect of BDNF and 5-HT
by: Jing Si, et al.
Published: (2021-04-01)

Application of a Fluorescent Biosensor in Determining the Binding of 5-HT to Calmodulin
by: L. X. Vásquez-Bochm, et al.
Published: (2021-09-01)

The serotonin 5-HT3 receptor: a novel neurodevelopmental target
by: Mareen eEngel, et al.
Published: (2013-05-01)

Gender-Specific Effect of 5-HT and 5-HIAA on Threshold Level of Behavioral Symptoms and Sex-Bias in Prevalence of Autism Spectrum Disorder
by: Barnali Chakraborti, et al.
Published: (2020-01-01)

Could peripheral 5-HT level be used as a biomarker for depression diagnosis and treatment? A narrative minireview
by: Canye Li, et al.
Published: (2023-03-01)

Azologization of serotonin 5-HT3 receptor antagonists
by: Karin Rustler, et al.
Published: (2019-03-01)

Seizure-dependent mTOR activation in 5-HT neurons promotes autism-like behaviors in mice
by: John J. McMahon, et al.
Published: (2015-01-01)

Quantitative changes in intracellular calcium and extracellular-regulated kinase activation measured in parallel in CHO cells stably expressing serotonin (5-HT) 5-HT<sub>2A </sub>or 5-HT<sub>2C </sub>receptors
by: Seitz Patricia K, et al.
Published: (2012-03-01)

Corrigendum: Could peripheral 5-HT level be used as a biomarker for depression diagnosis and treatment? A narrative minireview
by: Canye Li, et al.
Published: (2023-11-01)

Constitutively active 5-HT receptors: An explanation of how 5-HT antagonists inhibit gut motility in species where 5-HT is not a enteric neurotransmitter ?
by: Nick eSpencer
Published: (2015-12-01)

5-HT attenuates chronic stress-induced cognitive impairment in mice through intestinal flora disruption
by: Junxing Ma, et al.
Published: (2023-02-01)

5-HT1A Receptor Function Makes Wound Healing a Happier Process
by: Alia Sadiq, et al.
Published: (2018-12-01)

From behavioral context to receptors: serotonergic modulatory pathways in the IC
by: Laura M Hurley, et al.
Published: (2012-09-01)

5,7-Dimethoxycoumarin ameliorates vincristine induced neuropathic pain: potential role of 5HT3 receptors and monoamines
by: Muhammad Usman, et al.
Published: (2023-10-01)