Protein citrullination: A proposed mechanism for pathology in traumatic brain injury

Protein citrullination: A proposed mechanism for pathology in traumatic brain injury

Protein citrullination is a calcium-driven post-translational modification proposed to play a causative role in the neurodegenerative disorders of Alzheimer’s disease, multiple sclerosis (MS) and prion disease. Citrullination can result in the formation of antigenic epitopes that underlie pathogenic...

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Bibliographic Details
Main Authors: Rachel C Lazarus, John E Buonora, Michael N Flora, James G Freedy, Gay R Holstein, Giorgio P Martinelli, David M Jacobowitz, Gregory P Mueller
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Neurology
Subjects:
Astrocytes
Calcium
Glial Fibrillary Acidic Protein
Traumatic Brain Injury
citrullination
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00204/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00204/full

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