Engineered kinesin motor proteins amenable to small-molecule inhibition

Engineered kinesin motor proteins amenable to small-molecule inhibition

The use of specific small molecule inhibitors can contribute to the study of kinesins' cellular functions. Here the authors develop a chemical-genetic approach to engineer kinesin motors that can be efficiently inhibited upon addition of cell-permeable molecules.

Bibliographic Details
Main Authors: Martin F. Engelke, Michael Winding, Yang Yue, Shankar Shastry, Federico Teloni, Sanjay Reddy, T. Lynne Blasius, Pushpanjali Soppina, William O. Hancock, Vladimir I. Gelfand, Kristen J. Verhey
Format: Article
Language:English
Published: Nature Portfolio 2016-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11159

Internet

https://doi.org/10.1038/ncomms11159

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