Rosiglitazone suppresses RANKL‐induced NFATc1 autoamplification by disrupting the physical interaction between NFATc1 and PPARγ

Rosiglitazone suppresses RANKL‐induced NFATc1 autoamplification by disrupting the physical interaction between NFATc1 and PPARγ

Receptor activator of nuclear factor‐κB ligand (RANKL) is required for initiation of osteoclastogenesis, with the signaling pathway including the NF‐kB, c‐Fos, and nuclear factor of activated T cells, cytoplasmic 1 (NFATc1) transcription factors. Because NFATc1 expression is autoamplified, we invest...

Full description

Bibliographic Details
Main Authors: Kyeong‐Lok Park, Da‐Gyo Oh, Young‐Ok Kim, Kyeong‐Seob Song, Do‐Whan Ahn
Format: Article
Language:English
Published: Wiley 2018-10-01
Series:FEBS Open Bio
Subjects:
NFATc1
osteoclastogenesis
physical interaction
PPARγ
rosiglitazone
Online Access:https://doi.org/10.1002/2211-5463.12513

Internet

https://doi.org/10.1002/2211-5463.12513

Similar Items