Highly sensitive detection of driver mutations from cytological samples and cfDNA in lung cancer

Highly sensitive detection of driver mutations from cytological samples and cfDNA in lung cancer

Abstract Background Bronchoscopy is a minimally invasive procedure for establishing the diagnosis of lung cancer. It sometimes fails to obtain tissue samples but readily collects cytological samples. Methods We developed PNA‐LNA dual‐PCR (PLDP), which amplified mutant sequences by a high‐fidelity DN...

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Bibliographic Details
Main Authors: Kazutaka Fujita, Masayuki Nakayama, Masafumi Sata, Yoshiaki Nagai, Shu Hisata, Naoko Mato, Takuji Suzuki, Masashi Bando, Nobuyuki Hizawa, Koichi Hagiwara
Format: Article
Language:English
Published: Wiley 2021-12-01
Series:Cancer Medicine
Subjects:
cell‐free DNA
cytological samples
EGFR mutation
lung cancer
secondary mutation
Online Access:https://doi.org/10.1002/cam4.4330

Internet

https://doi.org/10.1002/cam4.4330

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