Changes in hemoglobin oxidation and band 3 during blood storage impact oxygen sensing and mitochondrial bioenergetic pathways in the human pulmonary arterial endothelial cell model

Changes in hemoglobin oxidation and band 3 during blood storage impact oxygen sensing and mitochondrial bioenergetic pathways in the human pulmonary arterial endothelial cell model

Red blood cells (RBCs) undergo metabolic, oxidative, and physiological changes during storage, collectively described as the “storage lesion.” The impact of storage on oxygen homeostasis, following transfusion, is not fully understood. We show that RBC storage induces changes in oxygen binding that...

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Bibliographic Details
Main Authors: Sirsendu Jana, Tigist Kassa, Francine Wood, Wayne Hicks, Abdu I. Alayash
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Physiology
Subjects:
aged RBC
oxidation
hemoglobin
pulmonary endothelial cells
band 3
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1278763/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2023.1278763/full

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