Slc39a2-Mediated Zinc Homeostasis Modulates Innate Immune Signaling in Phenylephrine-Induced Cardiomyocyte Hypertrophy

Slc39a2-Mediated Zinc Homeostasis Modulates Innate Immune Signaling in Phenylephrine-Induced Cardiomyocyte Hypertrophy

Zinc dyshomeostasis has been involved in the pathogenesis of cardiac hypertrophy; however, the dynamic regulation of intracellular zinc and its downstream signaling in cardiac hypertrophy remain largely unknown. Using Zincpyr1 staining, we found a significant decrease of intracellular Zinc concentra...

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Bibliographic Details
Main Authors: Yu Fang, Shun Wang, Jian Lv, Zhenyi Zhao, Ningning Guo, Gang Wu, Jingjing Tong, Zhihua Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
SLC39A2
zinc homeostasis
cardiac hypertrophy
innate immune signaling
feedback circuit
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.736911/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2021.736911/full

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