Metabolomics revealed mechanism for the synergistic effect of sulbactam, polymyxin-B and amikacin combination against Acinetobacter baumannii

Metabolomics revealed mechanism for the synergistic effect of sulbactam, polymyxin-B and amikacin combination against Acinetobacter baumannii

IntroductionThe emergence of multidrug-resistant (MDR) Acinetobacter baumannii prompts clinicians to consider treating these infections with polymyxin combination.MethodsMetabolomic analysis was applied to investigate the synergistic effects of polymyxin-B, amikacin and sulbactam combination therapy...

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Bibliographic Details
Main Authors: Shixing Zhu, Jiali Yue, Xintong Wang, Jiayuan Zhang, Mingming Yu, Yuanchao Zhan, Yuanqi Zhu, Sherwin K. B. Sy, Zhihua Lv
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Microbiology
Subjects:
Acinetobacter baumannii
metabolomics
polymyxin-B
amikacin
sulbactam significance
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1217270/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2023.1217270/full

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