Tetrapeptide Ac-HAEE-NH<sub>2</sub> Protects α4β2 nAChR from Inhibition by Aβ

Tetrapeptide Ac-HAEE-NH<sub>2</sub> Protects α4β2 nAChR from Inhibition by Aβ

The cholinergic deficit in Alzheimer’s disease (AD) may arise from selective loss of cholinergic neurons caused by the binding of Aβ peptide to nicotinic acetylcholine receptors (nAChRs). Thus, compounds preventing such an interaction are needed to address the cholinergic dysfunction. Recent finding...

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Bibliographic Details
Main Authors: Evgeny P. Barykin, Aleksandra I. Garifulina, Anna P. Tolstova, Anastasia A. Anashkina, Alexei A. Adzhubei, Yuri V. Mezentsev, Irina V. Shelukhina, Sergey A. Kozin, Victor I. Tsetlin, Alexander A. Makarov
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
nicotinic acetylcholine receptor
cholinergic deficit
peptide drugs
molecular modeling
β-amyloid
Online Access:https://www.mdpi.com/1422-0067/21/17/6272

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https://www.mdpi.com/1422-0067/21/17/6272

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