Characterization of a Conjugative Hybrid Plasmid Coharboring blaKPC-2 and blaIMP-4 in a Klebsiella quasipneumoniae Clinical Isolate

Characterization of a Conjugative Hybrid Plasmid Coharboring blaKPC-2 and blaIMP-4 in a Klebsiella quasipneumoniae Clinical Isolate

ABSTRACT Generation of hybrid MDR plasmids accelerated the evolution and transmission of resistance genes. In this study, we characterized a blaKPC-2- and blaIMP-4-coharboring conjugative hybrid plasmid constituted of an IncHI5 plasmid-like region, an IncFII(Yp)/IncFIA plasmid-like region, and a KPN...

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Bibliographic Details
Main Authors: Huiyue Dong, Ziyi Liu, Zhiyao Wu, Tingting Zhang, Ziwei Xia, Yuxin Zhao, Yan Li, Jinjin Shi, Zhiqiang Wang, Ruichao Li, Shangshang Qin
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:Microbiology Spectrum
Subjects:
K. quasipneumoniae
blaKPC-2
blaIMP-4
hybrid plasmid
IncHI5 plasmid
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02616-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.02616-22

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