Kaposi’s Sarcoma-Associated Herpesvirus-Encoded Viral IL-6 (vIL-6) Enhances Immunoglobulin Class-Switch Recombination

Kaposi’s Sarcoma-Associated Herpesvirus-Encoded Viral IL-6 (vIL-6) Enhances Immunoglobulin Class-Switch Recombination

Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic gamma-herpesvirus that causes AIDS-associated Kaposi sarcoma (KS) and several lymphoproliferative disorders. During the humoral immune response antigen-activated mature B cells acquire functional diversification by immunoglobulin heavy c...

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Bibliographic Details
Main Authors: Santas A. Rosario, Gabriel E. Santiago, Enrique A. Mesri, Ramiro E. Verdun
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Microbiology
Subjects:
Kaposi’s sarcoma-associated herpesvirus
viral IL-6
adaptive immunity
class-switch recombination
heavy chain constant region
microhomology
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.03119/full

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https://www.frontiersin.org/article/10.3389/fmicb.2018.03119/full

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