Endothelial Thioredoxin-Interacting Protein Depletion Reduces Hemorrhagic Transformation in Hyperglycemic Mice after Embolic Stroke and Thrombolytic Therapy

Endothelial Thioredoxin-Interacting Protein Depletion Reduces Hemorrhagic Transformation in Hyperglycemic Mice after Embolic Stroke and Thrombolytic Therapy

We hypothesize that endothelial-specific thioredoxin-interacting protein knock-out (EC-TXNIP KO) mice will be more resistant to the neurovascular damage (hemorrhagic-transformation-HT) associated with hyperglycemia (HG) in embolic stroke. Adult-male EC-TXNIP KO and wild-type (WT) littermate mice wer...

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Bibliographic Details
Main Authors: Mohd. Salman, Saifudeen Ismael, Lexiao Li, Heba A. Ahmed, Michelle A. Puchowicz, Tauheed Ishrat
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Pharmaceuticals
Subjects:
hyperglycemia
endothelial-specific TXNIP deletion
tissue plasminogen activator
hemorrhagic transformation
embolic stroke
Online Access:https://www.mdpi.com/1424-8247/14/10/983

Internet

https://www.mdpi.com/1424-8247/14/10/983

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